Pyruvate Protects against Cellular Senescence through the Control of Mitochondrial and Lysosomal Function in Dermal Fibroblasts

Mitochondrial dysfunction can drive cellular senescence, which is accompanied by changes in metabolism and increases in senescence-associated secretory phenotypes. Although pyruvate, a key metabolite for numerous aspects of metabolism, has been used as general supplement in synthetic media, the physiological Continue reading

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NAD to the Rescue.

The cofactor nicotinamide adenine dinucleotide (NAD) – once consigned to the oblivion of metabolic pathway wall charts – has recently attained celebrity status as the link between metabolic activity, cellular resistance to stress or injury, and longevity.

NAD influences many Continue reading

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The Resurgence of NAD+

Restoring a mitochondrial metabolite slows stem cell loss and aging. Cell Metabolism.

NAD was discovered over a century ago, and its role in cells as a redox conduit in metabolism was subsequently established. More recently, its oxidized form, NAD+, resurfaced Continue reading

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